Take I-5 north toward Vancouver. There are several border crossings you may choose to use, the two most popular of which are the Peace Arch crossing (right on I-5), and the Pacific Highway crossing (aka the "Truck Crossing" since it is the commerical point of entry from Washington State). Either choice is a good choice, depending on the border delays. You can check on the delays at http://www.cbsa-asfc.gc.ca/general/times/menu-e.html.
After crossing the border, continue north along Highway 99. After some 15 minutes, you will pass through the Massey Tunnel. Depending on the time of day, there will be anywhere from one to three lanes of traffic open northbound. In the case of only one northbound lane open, expect to see oncoming traffic in the "counterflow" lane of the tunnel. Continue north along Highway 99 through Richmond, crossing over the Oak Street Bridge. At this point, the highway blends into a typical Vancouver street, Oak Street. Continue north along Oak St. until 41st Avenue. Note that when you cross into Vancouver, the first intersection you pass through is 70th Avenue, and each block counts down as you proceed north.
Turn left on to 41st Avenue. Continue along 41st Ave until it merges with Southwest Marine Drive. Continue west along Southwest Marine Drive. Eventually Southwest Marine Drive becomes a highway as it leads out to the University. Soon, you will see an exit to 16th Avenue on the right-hand side. Take this exit. Take the left-hand lane and make the first left, on to East Mall. Continue along East Mall to find parking.